Just out | Linking species habitat and past palaeoclimatic events to evolution of the teleost innate immune system @ Proceedings of the Royal Society B

Just out @ Proceedings of the Royal Society B

Linking species habitat and past palaeoclimatic events to evolution of the teleost innate immune system


Monica Hongrø Solbakken, Kjetil Lysne Voje, Kjetill Sigurd Jakobsen, Sissel Jentoft


Host-intrinsic factors as well as environmental changes are known to be strong evolutionary drivers defining the genetic foundation of immunity. Using a novel set of teleost genomes and a time-calibrated phylogeny, we here investigate the family of Toll-like receptor (TLR) genes and address the underlying evolutionary processes shaping the diversity of the first-line defence. Our findings reveal remarkable flexibility within the evolutionary design of teleost innate immunity characterized by prominent TLR gene losses and expansions. In the order of Gadiformes, expansions correlate with the loss of major histocompatibility complex class II (MHCII) and diversifying selection analyses support that this has fostered new immunological innovations in TLRs within this lineage. In teleosts overall, TLRs expansions correlate with species latitudinal distributions and maximum depth. By contrast, lineage-specific gene losses overlap with well-described changes in palaeoclimate (global ocean anoxia) and past Atlantic Ocean geography. In conclusion, we suggest that the evolvability of the teleost immune system has most likely played a prominent role in the survival and successful radiation of this lineage.

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DOI: 10.1098/rspb.2016.2810

READ IT HERE: http://rspb.royalsocietypublishing.org/content/284/1853/20162810

Lurdes Fonseca

Assistant Professor and Researcher at University of Lisbon
Sociologist (PhD), Paleontologist (Researcher in Micropaleontology), Majors in Sociology and Biology, Minor in Geology. Main interests in Paleontology: Microfossils, Molecular fossils, Paleobiology and Paleoecology. (read more about me)